He thuziak hi Science X-in editorial kalphung leh policy a siam angin kan thlirlet a ni. Editor-te chuan thupui dik tak a nih theih nan a hnuaia miziate hi an ngaih pawimawh hle a ni:
Fungi leh bacteria pawn lam layer sticky tak, “extracellular matrix” emaw ECM tia koh hian jelly ang chi a nei a, venhimna layer leh shell angin a thawk bawk. Mahse tun hnaia journal iScience-a zirchianna an tihchhuah, University of Massachusetts Amherst-in Worcester Polytechnic Institute nena thawhhona an neihah, microorganism thenkhat ECM hian oxalic acid emaw acid awlsam dang emaw awmnaah chauh gel a siam a ni. A rilru a hah lutuk chuan a rilru a buai em em a, a rilru a hah lutuk chuan a rilru a buai em em bawk a. googletag.cmd.push(function() { googletag.display('div-gpt-ad-1449240174198-2′); });
ECM hian antibiotic laka invenna atanga pipe khar leh damdawi hmanrua tihbawlhhlawh thlengin hmun pawimawh tak a chang avangin, microorganism-te’n an sticky gel layer an tihchhiat dan hriatthiamna hian kan nitin nunah nghawng zau tak a nei a ni.
University of Massachusetts Amherst-a microbiology professor leh he paper ziaktu senior Barry Goodell chuan, “Microbial ECM hi ka ngaihven fo thin a ni,” a ti. “Miten ECM hi microorganisms humhimtu inert protective outer layer angin an ngai fo thin.Mahse, microbial cells chhunga nutrients leh enzymes te luh leh chhuah theihna tur conduit angin a thawk thei bawk.”.
Coating hian hna engemaw zat a thawk a: a stickiness awmzia chu microorganism pakhat zel chu an inzawm khawm thei a, colony emaw “biofilm” emaw an siam thei a, microorganism tling tawkin chutianga an tih chuan pipe a tikhawlo thei a, damdawi hmanrua a ti bawlhhlawh thei bawk.
Mahse a shell pawh hi permeable a ni tur a ni. Microorganism tam tak chuan ECM kaltlangin enzyme hrang hrang leh metabolite dangte chu an ei duh emaw, an kai duh emaw thil (thing ro emaw, vertebrate tissue emaw ang chi)-ah an paih chhuak a, chutah chuan enzyme-te chuan an chaw ei hna an thawh zawh chuan ECM kaltlangin ei tur tha tak takte chu an kalpui ta a ni. compound chu taksaah a insiam leh ta a ni. extracellular matrix a ni.
Hei hian ECM hi inert protective layer mai a ni lo tihna a ni a; Dik tak chuan Goodell leh a thawhpuiten an lantir angin microorganism te hian an ECM stickiness leh chuvangin an permeability control theihna an nei niin a lang. Engtin nge an tih? Thlalak hi B. Goodell hnen atanga lak a ni
Mushroom-ah chuan a secretion chu oxalic acid angin a lang a, hei hi organic acid tlanglawn tak a ni a, thing tam takah naturally a awm a ni. Goodell leh a thawhpuiten an hmuhchhuah angin microbe tam tak chuan an oxalic acid chhuah chu carbohydrates pawn lam layer-ah an inzawm a, sticky, gel ang chi ECM an siam niin a lang.
Mahse team hian ngun zawka an en chuan oxalic acid hian ECM siamnaah a pui mai bakah a “regulate” bawk tih an hmuchhuak a: microbes-te’n carbohydrate-acid mixture-a oxalic acid an dah tam poh leh ECM chu a viscous zual sauh sauh a ni. ECM hi a viscous deuh deuh chuan molecule lian tak tak microbe chhunga lut leh chhuah loh nan a block nasa zawk a, molecule te zawk erawh chu environment atanga microbe chhunga lut turin a zalen reng thung a, a lehlamah pawh a awm bawk.
He thil hmuhchhuah hian fungi leh bacteria-te’n compound chi hrang hrang an tihchhuahte chu heng microorganisms atanga boruak chhunga an luh tak tak dan chungchanga scientific hriatthiamna hlui chu a dodal a ni. Goodell leh a thawhpuiten thil engemaw takah chuan microorganism-te chuan an dam khawchhuahna emaw, a kai emaw theihna tura a innghahna matrix emaw tissue emaw beih nan molecule tenau tak tak chhuahnaah an rinchhan zawk a ngai mai thei niin an sawi.
Hei hian a awmzia chu enzyme lian zawkin microbial extracellular matrix a paltlang theih loh chuan molecule tenau secretion hian pathogenesis-ah pawh hmun pawimawh tak a chang thei tihna a ni.
Goodell-a chuan, “Middle ground a awm niin a lang a, chutah chuan microorganism-te chuan boruak pakhata insiamrem tûrin acidity level an control thei a, molecule lian zâwk ṭhenkhat, enzyme ang chite chu an vawng reng thei a, chutih rualin molecule tenau zâwkte chu ECM kal tlangin awlsam takin an kal thei a ni,” a ti.
Oxalic acid hmanga ECM modulation hi microorganisms te tan antimicrobial leh antibiotics laka invenna kawng a ni thei a, heng damdawi tam tak hi molecule lian tak tak atanga siam a nih avangin. He customization theihna hi antimicrobial therapy-a harsatna lian ber pakhat hneh theihna kawng pawimawh tak a ni thei a, ECM chu a permeable zawka siam tura manipulate chuan antibiotics leh antimicrobial te hnathawh thatna a tisang thei a ni.
“Microbe thenkhata oxalate ang chi acid te te biosynthesis leh secretion kan control theih chuan microbes chhunga lut tur pawh kan control thei a, hei hian microbial natna tam tak chu a ti tha zawk thei a ni,” tiin Goodell chuan a sawi.
Thu belhchian dawl zawk: Gabriel Perez-Gonzalez leh a thawhpuiten, Oxalates leh beta-glucan inzawmna: fungal extracellular matrix leh metabolite transport-a nghawng a neih dan, iScience (2023). DOI: 10.1016/j.isci.2023.106851 ah a tarlang bawk
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