I experience tihchangtlun nan cookies kan hmang thin. He site i tlawh chhunzawm zel hian cookies kan hman hi i pawm tihna a ni. Thu belhchian dawl zawk.
“Allow All” tih i click hian, site kal dan tihchangtlun nan, site hman dan thlirletna atan, leh a thlawna, open-access scientific content kan pekna tur kan thlawp theih nan i device-a cookies dah chu i remti a ni. Thu belhchian dawl zawk.
Zun test awlsam tak hian Alzheimer natna hmasa ber a hmuchhuak thei ang em, mass screening programme neihna tur kawng a hawng thei ang em? Frontiers in Aging Neuroscience zirchianna thar hian hei hi a tilang chiang hle. Hrilhfiahtute hian Alzheimer natna vei pawl lian tak, a nasat dan inang lo leh mi hrisel, cognitively normal, urine biomarker-a danglamna an hriat theih nan an test a ni.
An hmuhchhuah dan chuan zun chhunga formic acid hi subjective cognitive decline sensitive marker a ni a, Alzheimer natna hmasa ber a puang thei a ni. Alzheimer natna hriat theihna atana hmanraw awm tawhte chu a man a to a, a awlsam lo va, routine screening-ah pawh hman theih a ni lo. Chumi awmzia chu damlo tam zawk chu enkawlna \ha tak neih theih nan a tlai lutuk hunah chauh hmuhchhuah an ni tihna a ni. Mahse, non-invasive, man tlawm leh formic acid urinalysis awlsam tak chu doctor-te’n screening hmasa ber atana an dil ang chiah a ni thei.
“Alzheimer natna hi natna rei tak awm reng leh insidious tak a ni a, chu chu overt cognitive impairment a lo lan hmain kum tam tak chhung a lo awm thei a, a awm reng thei tihna a ni,” tiin ziaktute chuan an sawi. “Natna hmasa ber hi irreversible dementia stage hmaa thleng a ni a, hei hi intervention leh enkawlna atana rangkachak window a ni. Chuvangin, tarte zingah Alzheimer’s natna hmasa berte screening lian tak neih a ngai a ni.”.
Chuvangin, early intervention hi a pawimawh a nih chuan engvangin nge early stage Alzheimer’s disease hi routine screening program kan neih loh? Buaina chu tuna doctor-te’n diagnostic method an hman danah a awm a ni. Chung zingah chuan thluaka positron emission tomography a tel a, hei hi a man a to a, damlote chu radiation-ah a awmtir a ni. Alzheimer’s hriat theihna tur biomarker test pawh a awm a, mahse cerebrospinal fluid hmuh theih nan invasive blood draw emaw lumbar puncture emaw a ngai a, chu chu damlote chuan an tikhawtlai mai thei.
Mahse, zun test hi non-invasive leh awlsam tak a nih avangin mass screening atan a tha hle. Researcher-te chuan Alzheimer natna vei theihna tur urine biomarker hi a hmain an lo hmuchhuak tawh a, mahse natna hmasa ber hriat theihna tur pakhat mah hi a tha lo a, hei hian enkawl hmasakna tur golden window chu hmuh theih a la ni lo tihna a ni.
He zirchianna thar hnuaia zirchiangtute hian a hmain Alzheimer natna atana zun biomarker atana hman tur organic compound formaldehyde an lo zirchiang tawh a ni. Mahse, natna hriat hmasak kawngah hmasawnna tur a awm. He zirchianna hnuhnung berah hian formaldehyde metabolite formate chu biomarker angin a thawk tha zawk em tih an ngaihtuah a ni.
He zirchiannaah hian mi 574 an tel a, he zirchiannaa telte hi cognitively normal healthy volunteer emaw, natna zual zel dan hrang hrang nei emaw an ni a, subjective cognitive decline atanga natna tluantling thlengin an nei a ni. Zirchiangtute hian he huna telte zun leh thisen sample te an zirchiang a, psychological assessment an nei bawk.
He zirchiannaah hian Alzheimer’s disease group zawng zawngah urinary formic acid level chu a sang hle tih hmuhchhuah a ni a, healthy control-te nena khaikhin chuan cognitive decline nen a inzawm tih hmuhchhuah a ni a, early subjective cognitive decline group pawh a tel. Hei hian formic acid hi Alzheimer natna hmasa ber atan sensitive biomarker atan a thawk thei tih a tilang.
Ngaihven awm tak chu, zirchiangtute hian Alzheimer thisen biomarker nena inzawm urine formate level an zirchian khan damlo pakhatin natna a tawrh tur stage dik zawkin an sawi thei tih an hmuchhuak a ni. Mahse, Alzheimer natna leh formic acid inzawmna hriat chian nan zirchianna neih belh a ngai a ni.
“Urine formic acid hian Alzheimer natna screening hmasa ber atan sensitivity tha tak a nei a ni,” tiin ziaktute chuan an sawi. “Alzheimer natna atana zun biomarker test hi a awlsamin a man a tlawm a, tarte hriselna endikna pangngaiah pawh telh tur a ni.”.
Wang, Y. leh a dangte chuan. (2022) Alzheimer natna atana biomarker thar awm thei tur urinary formic acid chu systematic review. Tar chakna neurobiology-a ramri. A rilru a hah lutuk chuan a rilru a buai em em a. 10.3389/fnagi.2022.1046066.
Tags: tar chakna, Alzheimer natna, biomarker, thisen, thluak, natna khirh tak, natna khirh tak, compound, dementia, diagnostics, doctor, formaldehyde, neurology, positron emission tomography, zirchianna, tomography, urinalysis
Philadelphia, Pennsylvania-a Pittcon 2023-ah kumin chhunga Ralph N. Adams Prize in Analytical Chemistry dawngtu Professor Joseph Wang chu biosensor technology hman tangkai dan chungchang kan interview a.
He interview-ah hian Owlstone Medical-a Team Leader Mariana Leal nen respiratory biopsy chungchang leh natna hriat hmasakna atana biomarker zir chianna atana hmanraw tangkai tak a nih theih dan tur kan sawiho a ni.
SLAS US 2023 review kan neihnaah hian nakin lawka lab chungchang leh a awm dan tur chu Luigi Da Via, GSK Test Development Team Lead nen kan sawiho a ni.
News-Medical.Net hian he medical information service hi heng terms and conditions hnuaiah hian a pe a ni. He website-a damdawi lam thute hi damlo doctor/damdawi lam inzawmna leh damdawi lam thurawn an pek theihte thlawpna tur a ni a, a thlakna tur a ni lo tih hre reng ang che.