Fungi leh bacteria pawn lam layer sticky tak, “extracellular matrix” emaw ECM tia koh hian jelly ang chi a nei a, venhimna layer leh shell angin a thawk bawk. Mahse tun hnaia journal iScience-a zirchianna pakhat, University of Massachusetts Amherst-in Worcester Polytechnic Institute nena thawhhona an neihah chuan, microorganism thenkhat ECM hian oxalic acid emaw acid awlsam dang emaw awmnaah chauh gel a siam a ni. ECM hian antibiotic laka invenna atanga pipe khar leh damdawi hmanrua tihbawlhhlawh thlengin hmun pawimawh tak a chang avangin, microorganism-te’n an sticky gel layer an tihchhiat dan hriatthiamna hian kan nitin nunah nghawng zau tak a nei a ni.

University of Massachusetts Amherst-a microbiology professor leh he paper ziaktu senior Barry Goodell chuan, “Microbial ECM hi ka ngaihven fo thin a ni,” a ti. “Miten ECM hi microorganisms humhimtu inert protective outer layer angin an ngai fo thin.Mahse, microbial cells chhunga nutrients leh enzymes lut leh chhuak tur conduit angin a thawk thei bawk.”.
Coating hian hna engemaw zat a thawk a: a stickiness awmzia chu microorganism pakhat zel chu an inzawm khawm thei a, colony emaw “biofilm” emaw an siam thei a, microorganism tling tawkin chutianga an tih chuan pipe a tikhawlo thei a, damdawi hmanrua a ti bawlhhlawh thei bawk.
Mahse, a shell pawh hi permeable a ni tur a ni: microorganism tam tak chuan ECM kaltlangin enzyme hrang hrang leh metabolite dangte chu an paih chhuak a, an ei duh emaw, an kai duh emaw thil (thing ro emaw, vertebrate tissue emaw ang chi)-ah an paih chhuak a, chutah chuan, enzyme-te chuan an hna an thawh zawh chuan, chaw ei hna chu – ECM kaltlangin nutrients te chu an rawn thawn kir leh thin.
Hei hian ECM hi inert protective layer mai a ni lo tihna a ni a; Dik tak chuan Goodell leh a thawhpuiten an hmuhchhuah angin microorganism te hian an ECM viscosity leh chuvangin a permeability control theihna an nei niin a lang. Engtin nge an tih?
Fungi-ah chuan a chhuahna chu oxalic acid a ni tih a lang a, chu chu thing tam takah a pianphung anga awm, organic acid tlanglawn tak a ni a, Goodell leh a thawhpuiten an hmuhchhuah angin, microorganism tam tak chuan an oxalic acid chhuah chu carbohydrates pawn lam layer-te nena inzawm turin an hmang niin a lang. thil sticky tak siam chhuak. , jelly ang chi ECM.
Mahse team hian ngun zawka an en chuan oxalic acid hian ECM siamnaah a pui mai bakah a “regulate” bawk tih an hmuchhuak a: microbes-te’n carbohydrate-acid mixture-a oxalic acid an dah tam poh leh ECM chu a viscous zual sauh sauh a ni. ECM hi a viscous deuh deuh chuan molecule lian tak tak microbe chhunga lut leh chhuah loh nan a block nasa zawk a, molecule te zawk erawh chu environment atanga microbe chhunga lut turin a zalen reng thung a, a lehlamah pawh a awm bawk.
He thil hmuhchhuah hian fungi leh bacteria-te’n compound chi hrang hrang an tihchhuahte chu heng microorganisms atanga boruak chhunga an luh tak tak dan chungchanga scientific hriatthiamna hlui chu a dodal a ni. Goodell leh a thawhpuiten thil engemaw takah chuan microorganism-te chuan an dam khawchhuahna emaw, a kai emaw theihna tura a innghahna matrix emaw tissue emaw beih nan molecule tenau tak tak chhuahnaah an rinchhan zawk a ngai mai thei niin an sawi. Hei hian a awmzia chu enzyme lian zawkin microbial extracellular matrix a paltlang theih loh chuan molecule tenau secretion hian pathogenesis-ah pawh hmun pawimawh tak a chang thei tihna a ni.
Goodell-a chuan, “Middle ground a awm niin a lang a, chutah chuan microorganism-te chuan boruak bik nena inmil turin acidity level an control thei a, molecule lian zawk ṭhenkhat, enzyme ang chi chu an vawng reng thei a, chutih rualin molecule tenau zawkte chu awlsam takin ECM kaltlangin an kal thei a ni molecule lian tak tak a ni. He customization theihna hi antimicrobial therapy-a harsatna lian ber pakhat hneh theihna kawng pawimawh tak a ni thei a, ECM chu a permeable zawka siam tura manipulate chuan antibiotics leh antimicrobial te hnathawh thatna a tisang thei a ni.

“Microbe thenkhata oxalate ang chi acid te te biosynthesis leh secretion kan control thei a nih chuan microbes chhunga lut tur pawh kan control thei a, hei hian microbial natna tam tak chu a ti tha zawk thei a ni,” tiin Goodell chuan a sawi.
Kum 2022 December thla khan microbiologist Yasu Morita chuan National Institutes of Health aṭangin grant a dawng a, a tawpah chuan TB enkawlna thar, hlawk zawk siam chhuah tumna zirchianna a pui a ni.

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